Abstract
Summary
Isolated beating rat hearts perfused with [1,2-14C] acetaldehyde oxidize the compound to 14CO2. Inhibition of the oxidation by pretreatment in vivo with disulfiram suggests the involvement of a myocardial aldehyde dehydrogenase. The dehydrogenation of acetaldehyde may be rate-limiting since acetate oxidation to carbon dioxide proceeds faster than acetaldehyde oxidation in the perfused rat heart.
We are grateful to Steve Altman for helpful discussion and technical assistance.
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