Abstract
Summary
Perfused rat-lung cultures responded to inducers of interferon in a manner similar to that of cell cultures. Interferon was not detected in perfusion fluid after the exhibition of endotoxin and pyran co-polymer, but high titers of interferon were found after inoculation with Sindbis virus. Poly I-Poly C combined with DEAE-dextran stimulated interferon production which was inhibited partially by actinomycin D pre-treatment.
We are indebted to Miss Ruth Marie Jones and Mesdames Noreen Morrow and Deborah Miller for excellent technical assistance.
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