Abstract
Summary
Pseudomonas phaseolicola bacteriophage ⊘6 containing DS-RNA is capable of inducing interferon with a lower potency than with mycophage obtained from Penicillium stoloniferum. The smaller response with ⊘6 appears to be due to the lipid envelope surrounding the phage, since removal of lipid potentiates ⊘6's interferon-inducing capacity. ⊘6 DS-RNA induces high levels of interferon in mice and its interferon-inducing activity is somewhat greater than that seen with poly rI:rC.
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