Abstract
Summary
DH-524 is an agent which antagonizes the effects of some central nervous system depressants, but is without effect upon the narcosis produced by other depressants. This differentiates it from analeptics and stimulants which are nonspecific in their action. DH-524 is further differentiated by its failure to induce convulsions at nonfatal doses and its lack of effect upon spontaneous motor activity. In addition, DH-524 is an effective antagonist at doses which are well tolerated by nonnarcotized animals, while effective doses of bemegride were very toxic to non-narcotized animals. These data suggest that DH-524 would be more selective and have a wider margin of safety than the commonly used analeptics in the treatment of barbiturate or methaqualone overdose.
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