Abstract
Summary
New Zealand black/white hybrid mice spontaneously develop many auto-antibodies and a fatal immune-complex glomerulonephritis as part of an auto-immune process of unknown etiology. Amelioration of the nephritis of acute serum sickness in rabbits by antagonism of vasoactive amines prompted a therapeutic trial of the serotonin antagonist, methysergide, in NZB/W mice. When the drug was started early in life treated animals had less proteinuria and renal pathology than untreated controls.
We thank Miss Elinor Brown for excellent technical assistance and Mrs. Margaret Thompson for typing the manuscript.
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