Abstract
Summary
Isolated, perfused rat diaphragm has been studied with respect to the influences of muscle contraction and of ionic conditions upon the active accumulation of α-aminoiso-butyric acid, glycine and leucine. Muscle contractile activity increased the accumulation of AIB and glycine but not leucine. This finding provides evidence that at least two amino acid transporting systems exist in diaphragm muscle. The augmentation of AIB accumulation by muscle contraction is sensitive to sodium depletion in the extracellular fluid. Furthermore, augmented AIB transport in contracting muscle is closely related to the active transport of sodium.
The authors thank Dr. M. B. Visscher for his helpful assistance in the preparation of this paper.
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