Abstract
Summary
The isolated, perfused rabbit kidney was developed as a model system for evaluating platelet function. Kidneys perfused without platelets or with stored or clumped platelets showed an increase in weight and perfusion pressure, could not maintain surface hemostasis, and produced bloody urine. Perfusion with nonfunctional adenosine-treated platelets demonstrated similar changes without an increase in kidney weight. By contrast, organs perfused with fresh, acidified platelet concentrates from several species functioned well for the duration of perfusion. Pathologic changes in kidneys perfused under these various conditions were consistent with the functional changes observed.
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