Abstract
Summary
Ammonia concentrations were increased in portal blood and in cecal contents of nephrectomized compared to sham-operated control rats at 24 hr after surgery. Portal blood urea was increased 7- to 8-fold in both male and female nephrectomized rats compared to sham-operated controls. Portal concentrations of trans-aconitate, isocitrate and glucose were increased in male nephrectomized rats at 24 hr after surgery while in female rats, cis- and trans-aconitate, citrate and isocitrate were elevated in portal blood at 24 hr after surgery. The increase in citrate in female rats was quite marked at 24 hr while in male rats citrate was lower than control. Oral treatment of nephrectomized rats with caprylohydroxamic acid did not affect the survival time following nephrectomy, while treatment with neomycin in the drinking water for 3 days prior to nephrectomy significantly prolonged survival following nephrectomy.
Supported in part by NIH Gastroenterology Training Grant No. IT 01 AM05684-02 in the form of a postdoctoral traineeship stipend to R. L. P. The technical assistance of Mrs. Mabel Goetchius was appreciated.
Get full access to this article
View all access options for this article.