Abstract
Summary
Treatment of permissive or semi-restrictive cell lines with cytochalasin D (CD) enhances their susceptibility to infection with poliovirus. A two-to-threefold increase in the number of productively infected cells, as well as an augmented viral yield and a more rapid onset of cytopathic effects occur in drug-treated cultures. CD exerts its potentiating effect early after adsorption either during or, more probably, after viral penetration.
This work was supported by grant VC-76 from the American Cancer Society and grants CA-13835 and AI-06801-07 from the National Institutes of Health. We are grateful to Stanley G. Sawicki for many fruitful discussions and helpful suggestions.
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