Depression of Atrial Contractility by Peptides Isolated from Normal and Shock Plasma 1

Abstract

Summary

The presence of peptides in normal dog plasma and in plasma of dogs subjected to hemorrhagic shock has been investigated. The column chromatographic elution pattern for both normal and hemorrhagic plasma samples were similar. Of the six peptide peaks in the column elution pattern, only one (peak III) produced significant depression of atrial contractile strength. The depression produced by the shock peak III sample was not significantly greater than the contractile depression produced by control peak III. The results indicate that the atrial contractile depression produced by this peptide could only be significant during circulatory shock if it in some way interacted with other abnormal conditions existing during the shock state.