Abstract
Summary
There are two distinct categories of axenic mice: IgA producer strains and IgA nonproducer strains. This distinction is only possible in axenic mice, since both types synthesize a large amount of IgA when brought in a nonsterile environment. IgA producer strains have a transient but significant increase of serum IgA after corticoid treatment. Nonproducer strains have the same H2k locus in their genomes. The control of the serum IgA production or of the passage from the gut wall into the blood is multigenic.
The authors thank Dr. G. A. Voisin for reviewing the manuscript, Mrs. V. Lascaux and J. Prin for their technical assistance and Mrs. L. Guglielmi for the secretarial work. Mr. D. Briscoe is gratefully acknowledged for genetic advices and Mrs. J. Riddaway for translating into English the manuscript.
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