Diet-Induced Atherosclerosis in the Marmoset 1

Abstract

Summary

Atherosclerosis has been produced in captive cotton top marmosets fed a purified diet containing 5% cholesterol and 23% lard. The animals exhibited both sitespecific and time-related differences in vascular susceptibility to the disease. Atherosclerotic lesions in the lingual arteries and distal extensions of the coronary arteries antedated those in the aorta and other vulnerable vessels. The tongue arteries were particularly prone to atherosclerosis under the experimental conditions as demonstrated by the extent and severity of atheroma formation throughout the course of these vessels.