Abstract
Summary
When biologically equivalent amounts of riboflavin, 7-ethyl-8-methyl-flavin and 7-methyl-8-ethyl-flavin are being utilized by rats bearing Walker carcinoma 256, 7-ethyl-8-methyl-flavin is accumulated by the tumor in higher concentration than are the other two flavins. The SDH activity for the tumors utilizing 7-ethyl-8-methyl-flavin is reduced to approximately 20% of the value for the animals utilizing riboflavin, whether expressed in absolute units or in units per unit of tissue flavin. The tumor utilizes any one of the flavins for SDH activity more efficiently than the liver utilizes them for this enzyme.
Get full access to this article
View all access options for this article.