Abstract
Summary
The effects of pretreatment with estradiol benzoate on the pituitary release of LH and FSH in response to LH-RH were investigated in male rats at various time intervals after castration. In oil-treated control rats, LH-RH brought about a significant increase in serum LH at all the periods after castration. One day after castration, pretreatment with estradiol significantly inhibited the response to LH-RH, as observed in normal male rats. One week after castration estradiol induced a greater response to LH-RH than observed in oil-treated control rats, although the difference was not significant. One and two months after castration, estradiol significantly increased the response to LH-RH.
The authors express their gratitude to Dr. G. D. Niswender, Dr. H. Papkoff and to NIAMD, Rat Pituitary Program, for the gift of materials used in radioimmunoassays. Thanks are also given to Mr. L. Garcia, Mrs. M. Esslinger, and Mrs. J. Gauthier for technical assistance.
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