Abstract
Summary
In chronic cats, 5-HT injected into the caudate elicited tremors which were ascribed to a local excitatory effect. The 5-HT tremors developed rapidly, were of short duration and exhibited no tachyphylaxis. Tremor responses were readily antagonized by methysergide, reversibly suppressed by DA and prolonged by pargyline without a corresponding increase in amplitude. Development and maintenance of 5-HT tremor activity is substantially independent of cholinergic intervention. Based on its intracaudate profile of action and its ability to modify the neuroregulatory actions of local neurotransmitters (ACh, DA), 5-HT has been assigned a modulator role in the caudate.
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