Response of Plasma Lipids and Platelet Aggregation to Intravenous Arginine 1

Abstract

Summary

Intravenous administration of 400 ml 5% arginine in distilled water to 7 men and 10 women caused depression of plasma lipids and inhibition of epinephrine-induced platelet aggregation in men only. There was no depression of plasma lipids (except FFA) nor inhibition of platelet aggregation in women. 0.45% saline had no effect on plasma lipids or platelet aggregation. The similarity of response of plasma lipids and platelet aggregation in men following arginine with that after glucagon administration indicates the findings in men were probably due to stimulation of pancreatic glucagon secretion by arginine. No explanation can be given for the lack of response in women.