Abstract
Summary
Renin release rate (RPF) (RV—A renin) was measured in pentobarbital anesthetized rats. Plasma renin activities were determined by incubating plasma with purified rat renin substrate and measuring the angiotensin generated during the incubation by bioassay. It was found that the determinations could be made twice in an animal without measurable stimulation of renin release due to blood loss. Saline diuresis was found to inhibit renin release rate, and diminish arterial renin activity in rats.
These experiments were begun during a post-doctoral year at the Institut de Pharmacologie de l'Universite de Lausanne, Switzerland, supported by Postdoctoral Grant 49072 from the National Science Foundation. They were completed with support from Grant GB-31936 from the National Science Foundation and a grant from the Kidney Foundation of Michigan.
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