Abstract
Summary
Another humoral autoantibody tubular basement membrane antibody (TBMAb) has been demonstrated in the immune sera of Lewis rats in whom autoimmune nephrosis was produced by repeated intraperitoneal injections of a mixture containing complete Freund's adjuvant and a kidney tubular fraction obtained from normal Sprague-Dawley rats. The antibody, by indirect immunofluorescent technique, localized in a linear pattern along the normal tubular basement membrane and Bowman's capsule, but not along the glomerular basement membrane. Also the antibody (TBMAb) could be eluted from the immune deposits in the glomeruli of the diseased animals. These studies suggest the nephritogenicity of this antibody (TBMAb) and point out that at least two antigens (BBAg and TBMAg) may be nephritogenic in this form of experimental autoimmune nephrosis.
Addendum: It has been noted that TBM Ab develops only when Lewis rats are injected with Sprague-Dawley rat kidney and not vice versa.
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