Abstract
Summary
Rats with experimental chronic pyelonephritis were given a high sodium diet with fluid ad libitum and their body composition was determined. The rats with more severe pyelonephritis developed mild to moderate hypertension but analysis of fluid volumes and body electrolyte composition revealed no significant differences from normotensive pyelonephritic rats and nonpyelonephritic rats given the same diet. The results suggest that the elevation of blood pressure which develops in these rats is a consequence of an eventual increase in peripheral resistance, which results from processes of autoregulation following exposure to the increased sodium and fluid load.
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