Abstract
Summary and Conclusion
Saline extracts of the thymus of immunologically experienced animals (pig, calf, and guinea pig) have been shown by a new and very sensitive method to contain a macrophage migration inhibitory factor whose properties are similar to that of MIF obtained from the supernatant of transforming lymphocytes in vitro. This MIF activity could not be demonstrated in guinea pig or calf thymus until these animals had been immunologically stimulated by either soluble antigen or whole bacteria, however.
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