Abstract
Summary
Neurohypophysial and structurally related compounds elicit secretion of ACTH from suspensions of isolated pituitary cells. However, the maximum secretion of ACTH in response to the polypeptides is significantly less than that for an extract of rat hypothalamic median eminence (HME) tissue. When added in combination with appropriate doses of HME extract, argvasopressin inhibits ACTH secretion. These findings suggest that the neurohypophysial polypeptides may be partial agonists of corticotropin secretion.
The authors are grateful to Beth Wiblin-Portanova and James Larry Simmons for their technical assistance.
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