Abstract
Summary
The therapeutic effectiveness of daily doses of 100 μg of polyinosinic acid·polycytidylic acid (In·Cn) intraperitoneally was compared with two daily doses each of 0.25 ml containing 25,000 units/ml of mouse serum interferon intraperitoneally in protecting Semliki Forest virus infected mice. Mice receiving daily doses of In·Cn had a significantly lower mortality than did mice receiving the multiple doses of interferon. Combining In·Cn with poly-D-lysine resulted in a significantly enhanced interferon response to a single dose of In·Cn, and a similar greater therapeutic effect of a single dose of In·Cn plus poly-D-lysine was noted. Neither sustained higher levels of serum interferon nor increased protection were observed following multiple doses of In·Cn plus poly-D-lysine, as compared with multiple doses of In·Cn by itself. Pretreatment with 3 mg of COAM, which enhances the interferon response to In·Cn, significantly increased the therapeutic effect of a single dose of In·Cn.
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