Abstract
Summary
The effect of pyridoxine on the metabolism of Levodopa was studied in four normal volunteer subjects and five Parkinsonian patients. Each subject served as his own control. Co-administration of Levodopa and pyridoxine in Parkinsonian patients, but not in healthy subjects, significantly decreased DOPA excreted in urine and concomitantly increased urinary DA and DOPAC. Clinically worsened symptoms followed co-administration of pyridoxine and Levodopa in two of five Parkinsonians studied. These data suggest that pyridoxine enhances extracerebral metabolism of Levodopa in chronically treated Parkinsonian patients.
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