Abstract
Summary
The effect of contraceptive steroids on a strain of rats genetically predisposed to develop hypertension from ingestion of an excess of NaCl has been examined. Rats given CS grew more slowly and had a lower weight regardless of salt intake. CS enhanced the hypertension of rats receiving the high-salt diet but not of those eating a low-salt diet. CS had no effect on survival but salt intake did. This model offers the opportunity of studying the mechanism by which gonadal steroids enhance hypertension.
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