Abstract
Summary
Rats pretreated with various doses of Mycobacterium butyricum in mineral oil were protected against the induction of adjuvant disease 28 days later. Single 12.5 and 50 μg doses provided almost total protection. A 200 μg dose induced mild disease by itself, but prevented an anamnestic response following inductive challenge on the 28th day. Pretreatment with mineral oil alone afforded moderate, but significant protection. There were significant differences between these results and those obtained following inductive challenge on the 14th day.
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