Abstract
Summary
The predosing of rats with different doses of DSCG followed by a sufficient time interval so that the drug's effect was gone, then injection of another DSCG dose with antigen led to a high dose inhibition and low dose sparing of the second DSCG dose. The degree of sparing was concentration related and so was the degree of self-inhibition. These effects persisted for a 20-hr dosing regimen but were gone if one gave the last dose 48 hr before challenge.
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