Abstract
Summary
The prenatal administration of antibodies to bovine LH induces the same degree of hypospadias and nipple formation in newborn male rats as prenatal treatment with cyanoketone or antibodies to testosterone-3-bovine serum albumin, indicating a role for gonadotrophins in the testicular control of masculine organogenesis of the rat. Twenty-two days following parturition the adrenals are enlarged in mothers injected with cyanoketone during pregnancy while antibodies to bovine LH cause a reduction in maternal ovarian weight.
Bovine luteinizing hormone employed for immunization and purified rat pituitary hormone preparations utilized for characterization of anti-bovine LH serum were obtained from the Rat Hormone Distribution Program through the Hormone Distribution Officer, NIAMD, NIH.
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