Abstract
Summary
Disodium dichloromethylene diphosphonate (Cl2MDP) administered at 10 mg P/kg/day sc for 3 days to rats leads to a decreased blood calcium and decreased blood phosphate. The treated animals responded to a calcium load administered ip or iv with a larger increase in blood calcium and to a phosphate load with a larger decrease in blood calcium. It is suggested that this diminished efficiency in regulating blood calcium is due to the inhibiting effect of the diphosphonate on bone resorption.
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