Abstract
Summary
Male and female rats were treated for 5 days with phenobarbital and the four hepatic enzymes in the ascorbic acid pathway were assayed. In males, gulonate NADP-oxidoreductase were found to have decreased enzyme activity while glucuronolactone hydrolase activity remained unchanged. In females, gulonolactone hydrolase and gulonolactone-O2-oxidoreductase had decreased enzyme activity, gulonate-NADP-oxidoreductase remained unchanged while glucuronolactone hydrolase was found to have increased twofold in activity.
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