Abstract
Summary
The ability of essential and nonessential amino acids to stimulate the release of CCK was investigated in dogs using a bioassay procedure based on the perfusion of duodenojejunal Thiry-Vella loops and determining the increase of pancreatic protein response as well as the potentiation of pancreatic bicarbonate secretion induced by a background dose of secretin (0.2 units/kg/hr). All essential amino acids except threonine and all nonessential amino acids except cysteine and aspartic acid were effective in CCK release when perfused in equimolar concentration (50 mM) through the intestinal loop. The highest activity for release of CCK was exhibited by tryptophan and phenylalanine, which were also shown to release small amounts of secretin. The peak pancreatic protein response to tryptophan was 80% of the maximal response to exogenous CCK (25 units/kg/hr).
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