Abstract
Summary
An attempt was made to find some common site or mode of action for the numerous biological effects produced by leukocytic endogenous mediator (LEM). The effects of LEM on plasma iron concentration and number of blood neutrophils were compared in adrenalectomized and hypophysectomized rats by injecting intracisternally as compared to intravenously and after alteration of the concentration of catecholamines. The results obtained suggested that LEM was not acting through the adrenal or pituitary hormones or by modifying the levels of catecholamines. The results also indicated that the mechanism of fever production was different from the other changes produced by LEM.
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