Abstract
Summary
Male weanling rats were divided into 4 isonitrogenous dietary treatment groups, all of the dietary N and glutamic acid in groups A and B being derived from casein whereas 20% of the N and 65% of the glutamic acid in diets C and D were derived from MSG. Diets B and D contained 1% cholesterol. At the end of a 28-day feeding period, the rats receiving MSG (groups C and D) exhibited the following statistically significant differences from the rats receiving N only from casein (groups A and B): depressed weight gain, heavier kidneys, higher levels of serum albumin, lower levels of serum globulin, and a greater percent incorporation of an ip injection of 14C acetate into hepatic TNS lipid. Rats fed the diets containing 1% cholesterol (groups B and D) exhibited the following statistically significant differences from those fed the cholesterol-free diets (groups A and C): heavier livers, higher levels of serum albumin, globulin and total protein, greater concentration of hepatic cholesterol, and lower percent incorporation of an ip injection of 14C acetate into hepatic cholesterol.
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