Abstract
Summary
Evaluation of certain parameters of body fluids was carried out before and 1 wk following total denervation of the heart by a method which leaves nerves to other organs intact. In comparison with the normal state, dogs with denervated hearts showed an elevation of blood volume due almost entirely to an increase in the plasma component, little change in the volume of the interstitial space, and a large deficit of intracellular water. A loss of solute and water in the urine with solute leaving the cells to replace urinary losses could account for the decrease in the volume of the intracellular compartment. In the face of an elevated blood volume the concentration of ADH in plasma was diminished which was associated with a decreased urinary osmolality and increased urine volume following surgery.
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