Abstract
Summary
Parathyroid hormone (PTH), isoproterenol and norepinephrine stimulated adenyl cyclase activity of rat renal cortex. The effects of the latter two were abolished by propranolol but not by phentolamine. The effects of PTH were not influenced by these adrenergic blocking agents. Stimulation of the enzyme activity by a maximal dose of PTH was 3–4 times greater than that by a maximal dose of isoproterenol and the effects of both agonists were additive. These results indicate that in rat renal cortex there are two discrete adenyl cyclase systems responding independently to PTH and catecholamines, and the receptor for the latter agents being a beta adrenergic receptor.
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