Abstract
Summary
Nephrotensin, a newly described pressor agent which appears in the renal venous effluent of the ischemic kidney is not inactivated by angiotensin I antibody. It can also be differentiated from angiotensin I and II by the response to its injection of the rat's blood pressure and the perfusion pressure of the isolated rabbit's ear. These findings add further evidence that nephrotensin is a unique pressor agent responsible for the elevation in blood pressure observed in renovascular (surgically remediable) hypertension as observed in man and in the acute stage of experimental hypertension induced by drastic restriction of the renal artery or infarction of the kidney.
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