Angiotensins Lung Converting Enzyme 1

Abstract

Summary

Elevated systolic blood pressure was reduced to normal after treatment with CCl₄. Histological study of liver tissue primarily showed fatty metamorphosis in all the treated animals but cirrhotic changes in only 5 animals. Injection of angiotensin I produced an immediate pressor rise in renal CCl₄ treated rats showing no inhibition of lung converting enzyme. These findings indicate that lung-converting enzyme is probably not involved in the blood pressure reduction in this pathological condition.

I wish to thank Dr. J. Mackrell for his histopathologic interpretations, Dr. W. Whalen for his editorial advice, and Dr. L. Skeggs, who supplied the angiotensin I.