Abstract
Summary
Bilateral carotid occlusion (BC O) caused an average pressure increase of 64% in kidneys perfused at a constant rate of flow and a 20% reduction in flow when the perfusion pressure was held constant. Calculated renal resistance changed 64 and 29%, respectively. The responses to norepinephrine ia were also greater during CF perfusion than during CP perfusion. The results suggest that about one–half of the renal response to BCO during CF perfusion is due to the local resistance changes in response to the rise in perfusion pressure and about one–half due to the action of the vasoconstrictor nerves. In the perfused hind limb the response to each of these procedures during CF perfusion was a fraction of that seen during CP perfusion.
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