Abstract
Summary
Four major alkaloids isolated from Veratrum californicum—veratramine, veratrosine, cyclopamine, and muldamine— were fed to pregnant ewes during the fifth week of gestation. Cyclopamine, when administered during Days 28, 29, and 30 of gestation, produced the same congenital deformities of limbs previously produced by whole plants. These deformities included shortening of the metacarpal or metatarsal bones.
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