Abstract
Summary
Canine embryo cells were transformed in vitro by Kirsten murine sarcoma virus (Ki-MSV). The transformed cells contained group-specific complement-fixing antigen characteristic of the murine leukemiasarcoma virus complex. Cell-free supernatant fluids from the transformed cultures were infectious for rat, guinea pig, and canine embryo cells. RNA-dependent DNA polymerase activity was demonstrated in the transformed cells. Electron microscope observation showed that the transformed cells produced type C virus particles. The present results indicate that members of the murine sarcomaleukemia virus complex, particularly Ki-MSV, exhibit a broader host range than was hitherto believed.
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