Abstract
Summary
Doxapram-HCl effects ventilatory alterations in pentobarbital anaesthetized cats primarily by tidal volume elevations. Bilateral or unilateral ablation of the brain stem pneumotaxic center significantly reduces these doxapram-induced tidal volume elevations. Following bilateral pneumotaxic center lesions, the frequency responses elicited by doxapram administrations are significantly elevated. Apneusis is obtained in animals having bilateral pneumotaxic center lesions upon bilateral vagal section. It is concluded that the pontile pneumotaxic center plays a fundamental role in the regulation of doxapram-induced respiratory alterations.
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