Abstract
Summary
The inhibiting effect of an acid pH upon the induction of antiviral resistance by interferon was confirmed. Using this effect to block progression of antiviral resistance, a curve is described showing a transient arrest in the development of resistance 4 to 7 hr following contact of cells with interferon. The blocking effect of an acid pH is practically irreversible over a period of at least 12 hr following removal of the cells from the acid medium. This irreversibility appears not to be explained solely by inhibition of intracellular metabolism, and could relate to inhibition of a membrane-transport system by which externally bound interferon is received within the cell.
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