Abstract
Summary
Mice with thyrotropic pituitary tumors (TtT) invariably exhibit biologic gonadotropic activity. By immunohistochemical staining (IHCS), anti-thyrotropic hormone (TtH) in high dilutions was found to visualize strongly normal thyrotropes; the same sera also stained normal gonadotropes, albeit rather slightly and only when applied in higher concentrations. Anti-gonadotropic hormone (GtH) stained the gonadotropes intensely, but not the normal thyrotropes. However, it did stain TtT cells. Antisera to the corresponding β subunits stained normal and tumor cells almost as specifically as the antisera to the corresponding complete hormones. The anti-α sera were very weak and gave negative or weak, nonspecific reactions. Preliminary radioimmunoassays (RIA) indicated elevated GtH levels in sera of TtT-bearing mice.
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