Abstract
Summary
Oxygen consumption and succinic dehydrogenase activity were determined in whole cells and mitochondria isolated from peripheral leukocytes, tissue lymphocytes, and human leukemic cells. Tissue lymphocytes and leukemic leukocytes had higher respiratory activities than peripheral neutrophils and lymphocytes when calculated per mg protein, but not when expressed as a function of the number of cells. The fourfold increase in the activity of mitochondria isolated from tissue and leukemic cells compared to blood leukocytes suggests that the mitochondria in the former are more active but fewer in number.
Computation was done with the assistance of the Biological Sciences Computation Center, University of Chicago, under the U.S. Public Health Service Grant FR 00013 from the Division of Research Facilities and Resources of the National Institutes of Health.
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