Abstract
Summary
Intraperitoneally injected poly I:C resulted in a significant alteration of the peripheral WBC in mice. The effect was different on the various cell types: the number of circulating lymphocytes was reduced substantially for a period of up to two days. The number of granulocytes, especially the immature forms in the circulation, initially increased, followed by a moderate depression. The reduction was dose dependent, and to some extent corresponded to the titer of IF produced. Single-stranded poly I and poly C were without effect on the WBC, and no IF production could be detected.
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