“Metabolic Memory”: 1 Effects of Diets,Fed During the First Refeeding,on Hepatic Enzyme Responses,During a Second Starvation-Refeeding 2

Abstract

Summary

A second starvation-refeeding episode increases food intake and G6PD and ME activities compared with one cycle of starvation-refeeding. The increases can be obtained even if dietary protein or carbohydrate is omitted during the first refeeding, but not if a high-fat diet is fed during the first refeeding. The parallel changes in food intake, body weight changes, and enzyme responses suggest a basic, underlying adaptive response to caloric restriction which may have important nutritional implications.