Abstract
Summary
Despite in vitro inhibition by chloroquine of the replication of herpesvirus hominis types 1 and 2 in mouse embryo cell cultures, the course of in vivo infection of newborn mice was unaltered by chloroquine treatment. This discrepancy between in vitro and in vivo results suggest caution in the application of data derived from in vitro assays to the clinical therapy of herpesvirus infection. Plaques produced in BHK-21 cell cultures by HSV-1 and HSV-2 differed in appearance; this difference may prove useful for the presumptive identification of HSV isolates.
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