Abstract
Summary
Pilocarpine and physostigmine exhibit analgesia in the rat radiant heat tail-flick assay. This analgesia may be blocked by scopolamine or atropine. The mechanism of the analgesia produced by these cholinergic agents is of a central and not peripheral origin. Animals develop tolerance to the analgesic effects of both these drugs with chronic administration. Neostigmine fails to produce measurable analgesia.
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