Abstract
Summary
The effect of various inhibitors on the sodium-independent intracellular accumulation of 1 mM lysine and the sodium-independent stimulation of 1 mM lysine transmural transport by intracellular leucine was compared in intact rat intestine. Five millimolar ethacrynic acid, 1 mM sodium fluoride, and 5 mM probenecid did not inhibit either of these sodium-independent lysine transport systems while 0.4 mM DNP and 5 mM ATP inhibited both. NEM (0.4 mM) decreased lysine intracellular accumulation but not leucine-stimulated lysine transport. These results show that the action of the inhibitors on these two sodium-independent lysine transport systems are generally similar.
Get full access to this article
View all access options for this article.