Abstract
Summary
The distribution of 45Ca to the subcellular components of the heart and skeletal muscle of five strains of mice varies to a remarkable degree in the first hour after intravenous injection. Tissues from CBA and C57 bound less isotope than SJL, CF-1 or DBA. Most of the bound 45Ca was found in the heaviest fraction of heart homogenates while distribution was more uniform in the centrifugal fractions of skeletal muscle. The mitochondria in hearts of DBA mice which showed visible areas of calcification bound much less 45Ca than the same fraction of normal DBA mice. Skeletal muscle from these mice also differed from that of normal mice of the same strain in the extent of isotope binding.
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