Analysis of Fd Antigen in Gamma and Mu Paraproteins with Shared Idiotypy 1

Abstract

Summary

The carboxy half of Fd of IgG has previously been shown to be an antigen common to IgG proteins. In this report the antigenic determinants were not found in an IgM paraprotein with a region of idiotypy similar to that of an IgG paraprotein which contained them. The available data suggest that the antigenic determinants are contained between residue Nos. 120 and 216, the C_H1 region of IgG.